Historical Figure
Har Gobind Khorana
b. 1922
Indian-American molecular biologist (1922–2011)
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Biography
Har Gobind Khorana was an Indian-American biochemist. While on the faculty of the University of Wisconsin–Madison, he shared the 1968 Nobel Prize for Physiology or Medicine with Marshall W. Nirenberg and Robert W. Holley for research that showed the order of nucleotides in nucleic acids, which carry the genetic code of the cell and control the cell's synthesis of proteins. Khorana and Nirenberg were also awarded the Louisa Gross Horwitz Prize from Columbia University in the same year.
Timeline
The story of Har Gobind Khorana, told in moments.
Synthesized functional genes outside a living cell for the first time. He built DNA sequences nucleotide by nucleotide. Nobody else had the patience or precision.
Won the Nobel Prize in Physiology or Medicine for cracking the genetic code. He showed which three-letter DNA sequences correspond to which amino acids. Shared the prize with Robert Holley and Marshall Nirenberg.
Synthesized the first artificial gene. Built it from scratch using organic chemistry. The gene was functional. This opened the door to genetic engineering.
Artifacts (15)
I don't fool myself. I can't see myself doing Shakespeare.
ing around London, and also contained a brief interview with her. Asked about her acting ambitions, she replied, "I don't fool myself. I can't see myself doing Shakespeare." She spoke of her hopes of...
a light comedienne in the Carole Lombard style
f doing Shakespeare." She spoke of her hopes of finding a niche in comedy and, in other interviews, she expressed her desire to become "a light comedienne in the Carole Lombard style". Later in the...
all a fairly respectful admirer of movies can do is laugh at it and turn away
style". Later in the year, Valley of the Dolls opened to almost uniformly negative reviews. Bosley Crowther wrote in The New York Times, "all a fairly respectful admirer of movies can do is laugh at...
The only nice thing is Sharon Tate, a tall, really great-looking girl.
s praising her comedic performance. The New York Times critic Vincent Canby criticized the film but wrote, "The only nice thing is Sharon Tate, a tall, really great-looking girl." Martin commented...
We have a good arrangement. Roman lies to me and I pretend to believe him.
ugh she confided to friends that she hoped that he would change. Peter Evans quoted Tate as saying, "We have a good arrangement. Roman lies to me and I pretend to believe him." Polanski urged Tate to...
has no more sense of its own ludicrousness than a village idiot stumbling in man...
he New York Times, "all a fairly respectful admirer of movies can do is laugh at it and turn away". Newsweek said that the film "has no more sense of its own ludicrousness than a village idiot...
the imperfect couple. They were the Douglas Fairbanks/Mary Pickford of our time…...
e couple moved into Polanski's mews house off Eaton Square in Belgravia, London. Photographer Peter Evans described them as "the imperfect couple. They were the Douglas Fairbanks/Mary Pickford of our...
continually treated [Tate] like an imbecile, which she definitely was not, and s...
hree principal actresses but, according to Duke, directed most of his criticism at Tate. Duke later said that Robson "continually treated [Tate] like an imbecile, which she definitely was not, and she...
Ten years ago ... Parkins, Duke, and Tate would more likely have been playing th...
three lead actresses were castigated in numerous publications, including The Saturday Review, which wrote, "Ten years ago ... Parkins, Duke, and Tate would more likely have been playing the hat check...
We even agreed that if after the first two weeks Sharon was not quite making it,...
director J. Lee Thompson, who expressed his initial doubts about Tate's potential with the comment, "We even agreed that if after the first two weeks Sharon was not quite making it, we would put her...
I learned a great deal about acting in [Valley of the Dolls], particularly in my...
iration for Lee Grant, with whom she had played several dramatic scenes. Tate was quoted as saying, "I learned a great deal about acting in [Valley of the Dolls], particularly in my scenes with Lee...
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